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Drugs in the 2C family usually come in the form of capsules or tablets that are swallowed or a powder form that is snorted. They may also come in liquid form.

Typical doses of 2C drugs usually range from 10 to 30 milligrams. The effects of 2C-E typically last for eight to 12 hours, but some 2C drugs can last for 24 hours or longer. Snorting the drugs causes a more rapid onset of effects than swallowing them does.

Occasionally, people mix 2C drugs with other hallucinogens. The combination of 2C-B and LSD is known as a banana split, while mixing 2C-B and MDMA is called a party pack

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It is commonly active in the 10–20 mg range, taken orally or nasally and highly dose-sensitive. Insufflating (snorting) requires a much lower dose, typically not exceeding 10 mg, but this method of consumption elicits an extremely painful sensation in the nasal cavity for 10 minutes or so. Shulgin classified 2C-E as a member of the “Magical Half-Dozen” in his book PiHKAL: A Chemical Love Story. Many have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense. Vivid visuals similar to those experienced while under the influence of LSD are common, and many reports indicate that the effects of this particular chemical may be overly intense for those not well experienced with psychedelics.