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Ketamin, As with other general anesthetic agents, the individual response to ketamine hydrochloride is somewhat varied depending on the dose. Ketamine, The drug should be titrated against the patient’s requirements, Ketamine Injection.
Ketamine is a medication mainly used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include sedation in intensive care and treatment of pain and depression.
CAS ID: 6740-88-1
Other names: CI-581; CL-369; CM-52372-2
Duration of action: : Intramuscular: 0.5–2 hours; Insufflation: 45–60 min; By mouth: 1–6+ hours;
Elimination half-life: : Ketamine: 2.5–3 hours; Norketamine: 12 hours;
Metabolism: Liver (N-demethylation):: Major: CYP3A4; Minor: CYP2B6, CYP2C9
Melting point: 258 to 261 °C (496 to 502 °F)
ketamine for Pain, ketamine effects, Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2- (methylamino) cyclohexanone hydrochloride. ketamine depression treatment, It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrations containing the equivalent of either 10, ketamine pills, 50 or 100 mg ketamine base per milliliter and contains not more than 0.1 mg/mL Phemerol (benzethonium chloride) added as a preservative. ketamine for anxiety, The 10 mg/mL solution has been made isotonic with sodium chloride, ketamine infusion. ketamine clinic, ketamine high.
Ketamine hydrochloride injection is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. Ketamine injection, Ketamine hydrochloride is best suited for short procedures but it can be used, with additional doses, for longer procedures.
Ketamine hydrochloride injection is indicated for the induction of anesthesia prior to the administration of other general anesthetic agents.
Ketamine hydrochloride injection is indicated to supplement low-potency agents, such as nitrous oxide.
Specific areas of application are described in the CLINICAL PHARMACOLOGY section.
DOSAGE AND ADMINISTRATION
Note: ketamine high, Barbiturates and ketamine hydrochloride, being chemically incompatible because of precipitate formation, should not be injected from the same syringe.
If the ketamine hydrochloride dose is augmented with diazepam, the two drugs must be given separately. Do not mix ketamine hydrochloride and diazepam in syringe or infusion flask. ketamine side effects, For additional information on the use of diazepam, refer to the WARNINGS and DOSAGE AND ADMINISTRATION Sections of the diazepam insert.
While vomiting has been reported following ketamine hydrochloride administration, some airway protection may be afforded because of active laryngeal-pharyngeal reflexes. ketamine injection, However, since aspiration may occur with ketamine hydrochloride and since protective reflexes may also be diminished by supplementary anesthetics and muscle relaxants, the possibility of aspiration must be considered. ketamine therapy, Ketamine hydrochloride is recommended for use in the patient whose stomach is not empty when, in the judgment of the practitioner, the benefits of the drug outweigh the possible risks.
Atropine, scopolamine, or another drying agent should be given at an appropriate interval prior to induction.
Onset And Duration
Because of rapid induction following the initial intravenous injection, the patient should be in a supported position during administration.
The onset of action of ketamine hydrochloride is rapid; ketamine and depression, ketamine effects, an intravenous dose of 2 mg/kg (1 mg/lb) of body weight usually produces surgical anesthesia within 30 seconds after injection, ketamine clinic, with the anesthetic effect usually lasting five to ten minutes. ketamine definition, ketamine effects, If a longer effect is desired, additional increments can be administered intravenously or intramuscularly to maintain anesthesia without producing significant cumulative effects.
Intramuscular doses, ketamine effects, in a range of 9 to 13 mg/kg (4 to 6 mg/lb) usually produce surgical anesthesia within 3 to 4 minutes following injection, ketamine high, ketamine clinic, with the anesthetic effect usually lasting 12 to 25 minutes.
As with other general anesthetic agents, the individual response to ketamine hydrochloride is somewhat varied depending on the dose, route of administration, and age of the patient, so that dosage recommendation cannot be absolutely fixed. The drug should be titrated against the patient’s requirements.
The initial dose of ketamine hydrochloride administered intravenously may range from 1 mg/kg to 4.5 mg/kg (0.5 to 2 mg/lb). ketamine treatment for depression, The average amount required to produce five to ten minutes of surgical anesthesia has been 2 mg/kg (1 mg/lb). Buy Ketamine Injection Online.